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Effects of continuous high-dose G-CSF administration on hematopoietic stem cell mobilization and telomere length in patients with amyotrophic lateral sclerosis – a pilot study

Iberl, Sabine ; Meyer, Anne-Louise ; Müller, Gunnar ; Peters, Sebastian ; Johannesen, Siw ; Kobor, Ines ; Beier, Fabian ; Brümmendorf, Tim H. ; Hart, Christina ; Schelker, Roland ; Herr, Wolfgang ; Bogdahn, Ulrich ; Grassinger, Jochen


Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease of complex and still poorly understood etiology. Loss of upper and lower motoneurons results in death within few years after diagnosis. Recent studies have proposed neuroprotective and disease-slowing effects of granulocyte-colony stimulating factor (G-CSF) treatment in ALS mouse models as well as humans. In this study, six ALS ...


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