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Comparative Analysis of Microfluidics Thrombus Formation in Multiple Genetically Modified Mice: Link to Thrombosis and Hemostasis

Nagy, Magdolna ; van Geffen, Johanna P. ; Stegner, David ; Adams, David J. ; Braun, Attila ; de Witt, Susanne M. ; Elvers, Margitta ; Geer, Mitchell J. ; Kuijpers, Marijke J. E. ; Kunzelmann, Karl ; Mori, Jun ; Oury, Cécile ; Pircher, Joachim ; Pleines, Irina ; Poole, Alastair W. ; Senis, Yotis A. ; Verdoold, Remco ; Weber, Christian ; Nieswandt, Bernhard ; Heemskerk, Johan W. M. ; Baaten, Constance C. F. M. J.



Abstract

Genetically modified mice are indispensable for establishing the roles of platelets in arterial thrombosis and hemostasis. Microfluidics assays using anticoagulated whole blood are commonly used as integrative proxy tests for platelet function in mice. In the present study, we quantified the changes in collagen-dependent thrombus formation for 38 different strains of (genetically) modified mice, ...

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