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Synthesis and biological evaluation of heteroalicyclic cyanoguanidines at histamine receptors

Soliman, Beatrice ; Wang, Ning ; Zagotto, Giuseppe ; Pockes, Steffen


Recent studies on histamine receptor (HR) subtypes identified imidazolyl butyl cyanoguanidines, like UR-PI376, as highly potent agonists at the human histamine H-4 receptor (hH(4)R). While imidazole-containing compounds display drawbacks in pharmacokinetics, we studied the possibility of replacing the heteroaromatic cycle by nonaromatic six-membered heterocycles (piperidine, morpholine, ...


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