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Heat-killed Mycobacterium tuberculosis prime-boost vaccination induces myeloid-derived suppressor cells with spleen dendritic cell–killing capability

Ribechini, Eliana ; Eckert, Ina ; Beilhack, Andreas ; Du Plessis, Nelita ; Walzl, Gerhard ; Schleicher, Ulrike ; Ritter, Uwe ; Lutz, Manfred B.



Abstract

Tuberculosis patients and mice infected with live Mycobacterium tuberculosis accumulate high numbers of myeloid-derived suppressor cells (MDSCs), Here, we hypothesized that dead M. tuberculosis vaccines also may induce MDSCs that could impair the efficacy of vaccination. We found that repeated injections of M. tuberculosis vaccines (heat-killed M. tuberculosis in incomplete Freund's adjuvant, ...

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