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Chromatin remodeler Ep400 ensures oligodendrocyte survival and is required for myelination in the vertebrate central nervous system

Elsesser, Olga ; Fröb, Franziska ; Küspert, Melanie ; Tamm, Ernst R ; Fujii, Toshihiro ; Fukunaga, Rikiro ; Wegner, Michael



Abstract

Differentiating oligodendrocytes generate myelin to ensure rapid saltatory conduction in the vertebrate central nervous system. Although oligodendroglial differentiation and myelination are accompanied by dramatic chromatin reorganizations, previously studied chromatin remodelers had only limited direct effects on the process. To study the functional significance of chromatin changes for ...

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