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Tooth agenesis-related GLI2 and GLI3 genes may contribute to craniofacial skeletal morphology in humans

Marañón-Vásquez, Guido Artemio ; Dantas, Beatriz ; Kirschneck, Christian ; Arid, Juliana ; Cunha, Arthur ; Ramos, Alice Gomes de Carvalho ; Omori, Marjorie Ayumi ; Rodrigues, Amanda Silva ; Teixeira, Ellen Cardoso ; Levy, Simone Carvalho ; Schroeder, Agnes ; Matsumoto, Mírian Aiko Nakane ; Proff, Peter ; Antunes, Lívia Azeredo A. ; Vieira, Alexandre R. ; Antunes, Leonardo Santos ; Küchler, Erika Calvano


Objective: The present cross-sectional, multi-centre, genetic study aimed to determine, whether single nucleotide polymorphisms (SNPs) in tooth agenesis (TA)-associated GLI2 and GLI3 genes contribute to the development of craniofacial skeletal morphology in humans. Design: Orthodontic patients from an ethnically heterogeneous population were selected for the present study (n = 594). The presence ...


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