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BioScore (B7-H1, survivin, and Ki-67) does not predict cancer-specific mortality in surgically treated patients with renal cell carcinoma: An external validation study

Hutterer, Georg C. ; Posch, Florian ; Buser, Lorenz ; Zigeuner, Richard ; Morshäuser, Laura ; Otto, Wolfgang ; Wild, Peter J. ; Burger, Maximilian ; May, Matthias ; Pichler, Martin ; Brookman-May, Sabine D.


Background: To externally validate, BioScore', a biomarker-based scoring system using immunohistochemical tumor expression levels of B7-H1, survivin, and Ki-67, in a single-center cohort of renal cell carcinoma (RCC) patients. Additionally, we investigated the potential benefit of BioScore as compared to the Mayo Clinic stage, size, grade, and necrosis (SSIGN) score. Materials and Methods: The ...


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