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Microfluidic enrichment, isolation and characterization of disseminated melanoma cells from lymph node samples

Weidele, Kathrin ; Stojanović, Nataša ; Feliciello, Giancarlo ; Markiewicz, Aleksandra ; Scheitler, Sebastian ; Alberter, Barbara ; Renner, Philipp ; Haferkamp, Sebastian ; Klein, Christoph A. ; Polzer, Bernhard


For the first time in melanoma, novel therapies have recently shown efficacy in the adjuvant therapy setting, which makes companion diagnostics to guide treatment decisions a desideratum. Early spread of disseminated cancer cells (DCC) to sentinel lymph nodes (SLN) is indicative of poor prognosis in melanoma and early DCCs could therefore provide important information about the malignant seed. ...


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