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FimH-based display of functional eukaryotic proteins on bacteria surfaces

Chmielewski, Markus ; Kuehle, Johannes ; Chrobok, Danuta ; Riet, Nicole ; Hallek, Michael ; Abken, Hinrich



Abstract

The demand for recombinant proteins for analytic and therapeutic purposes is increasing; however, most currently used bacterial production systems accumulate the recombinant proteins in the intracellular space, which requires denaturating procedures for harvesting and functional testing. We here present a novel FimH-based expression system that enables display of fully functional eukaryotic ...

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