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MTHFD1 interaction with BRD4 links folate metabolism to transcriptional regulation

Sdelci, Sara ; Rendeiro, André F. ; Rathert, Philipp ; You, Wanhui ; Lin, Jung-Ming G. ; Ringler, Anna ; Hofstätter, Gerald ; Moll, Herwig P. ; Gürtl, Bettina ; Farlik, Matthias ; Schick, Sandra ; Klepsch, Freya ; Oldach, Matthew ; Buphamalai, Pisanu ; Schischlik, Fiorella ; Májek, Peter ; Parapatics, Katja ; Schmidl, Christian ; Schuster, Michael ; Penz, Thomas ; Buckley, Dennis L. ; Hudecz, Otto ; Imre, Richard ; Wang, Shuang-Yan ; Maric, Hans Michael ; Kralovics, Robert ; Bennett, Keiryn L. ; Müller, Andre C. ; Mechtler, Karl ; Menche, Jörg ; Bradner, James E. ; Winter, Georg E. ; Klavins, Kristaps ; Casanova, Emilio ; Bock, Christoph ; Zuber, Johannes ; Kubicek, Stefan



Abstract

The histone acetyl reader bromodomain-containing protein 4 (BRD4) is an important regulator of chromatin structure and transcription, yet factors modulating its activity have remained elusive. Here we describe two complementary screens for genetic and physical interactors of BRD4, which converge on the folate pathway enzyme MTHFD1 (methylenetetrahydrofolate dehydrogenase, cyclohydrolase and ...

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