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De Novo Protein Synthesis Mediated by the Eukaryotic Elongation Factor 2 Is Required for the Anxiolytic Effect of Oxytocin

Martinetz, Stefanie ; Meinung, Carl-Philipp ; Jurek, Benjamin ; von Schack, David ; van den Burg, Erwin H. ; Slattery, David A. ; Neumann, Inga D.


BACKGROUND: The neuropeptide oxytocin (OXT) mediates its actions, including anxiolysis, via its G protein-coupled OXT receptor. Within the paraventricular nucleus of the hypothalamus (PVN), OXT-induced anxiolysis is mediated, at least in part, via activation of the mitogen-activated protein kinase pathway following calcium influx through transient receptor potential cation channel subfamily V ...


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