| Item type: | Article | ||||
|---|---|---|---|---|---|
| Höhe Gebühr (aus OpenAPC): | 1694.56 | ||||
| Institution der Zahlung: | Leipzig U | ||||
| Journal or Publication Title: | PLOS ONE | ||||
| Publisher: | PLOS | ||||
| Place of Publication: | SAN FRANCISCO | ||||
| Volume: | 14 | ||||
| Number of Issue or Book Chapter: | 5 | ||||
| Page Range: | e0216530 | ||||
| Date: | 2019 | ||||
| Institutions: | Medicine > Lehrstuhl für Innere Medizin II | ||||
| Identification Number: |
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| Keywords: | PATENT FORAMEN OVALE; TRANSIENT ISCHEMIC ATTACK; TRANSESOPHAGEAL ECHOCARDIOGRAPHY; ATRIAL-FIBRILLATION; MEDICAL THERAPY; TRANSTHORACIC ECHOCARDIOGRAPHY; EARLY MANAGEMENT; CLOSURE; GUIDELINES; AGE; | ||||
| Dewey Decimal Classification: | 600 Technology > 610 Medical sciences Medicine | ||||
| Status: | Published | ||||
| Refereed: | Yes, this version has been refereed | ||||
| Created at the University of Regensburg: | Yes | ||||
| Item ID: | 48673 |
Web of ScienceAbstract
Background The cardiac diagnostic workup of stroke patients, especially the value of echocardiography and enhanced and prolonged Holter-ECG monitoring, is still a matter of debate. We aimed to analyse the impact of pathologies detected by echocardiography and ECG monitoring on therapeutic decisions and prognosis. Methods Find-AF(RANDOMISED) was a prospective multicenter study which randomised 398 ...
Abstract
Background The cardiac diagnostic workup of stroke patients, especially the value of echocardiography and enhanced and prolonged Holter-ECG monitoring, is still a matter of debate. We aimed to analyse the impact of pathologies detected by echocardiography and ECG monitoring on therapeutic decisions and prognosis. Methods Find-AF(RANDOMISED) was a prospective multicenter study which randomised 398 acute ischemic stroke patients >= 60 years to enhanced and prolonged Holter-ECG monitoring or usual stroke unit care. This substudy compared therapeutic consequences of echocardiography and routine Holter-ECG or enhanced and prolonged Holter-ECG monitoring, respectively, and prognosis of patients with or without pathologic findings in echocardiography or Holter-ECG monitoring. Results 50.3% received enhanced and prolonged Holter-ECG monitoring and 49.7% routine ECG monitoring. 82.9% underwent transthoracic echocardiography (TTE), 38.9% transesophageal echocardiography (TEE) and 25.6% both procedures. 14/89 TEE pathologies and 1/90 TTE pathology led to a change in therapy, resulting in a number needed to change decision (NNCD) of 12 and 330 (p < 0.001), respectively. In comparison, enhanced and prolonged Holter-ECG monitoring found atrial fibrillation (AF) in 27 of 200 patients, and routine ECG monitoring in twelve of 198 patients, leading to therapeutic changes in all patients (NNCD 8 and 17, respectively, p < 0.001). Conclusions Most changes in therapeutic decisions were triggered by enhanced and prolonged Holter-ECG monitoring, which should therefore play a more prominent role in future guidelines. Echocardiography identifies a patient group at high cardiovascular risk, but rarely result in therapeutic changes. Whether this patient group requires further cardiovascular workup remains unknown. This should be further investigated by interdisciplinary neurocardiologic teams and in appropriate future trials.
Metadata last modified: 03 Sep 2021 10:02
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