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Fluorescein Sodium in the Surgical Treatment of Recurrent Glioblastoma Multiforme

Höhne, Julius ; Schebesch, Karl-Michael ; de Laurentis, Camilla ; Akçakaya, Mehmet Osman ; Pedersen, Christian Bonde ; Brawanski, Alexander ; Poulsen, Frantz Rom ; Kiris, Talat ; Cavallo, Claudio ; Broggi, Morgan ; Ferroli, Paolo ; Acerbi, Francesco


BACKGROUND: Glioblastoma multiforme (GBM) is the most common primary brain tumor and has a high recurrence rate. Maximizing the extent of resection (EOR) in recurrent GBM has proved to be the cornerstone of neurosurgical retreatment. The development of surgical microscopes fitted with fluorescein-specific filters has facilitated fluorescein-guided microsurgery and the identification of tumor ...


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