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Metabolic, Anti-apoptotic and Immune Evasion Strategies of Primary Human Myeloma Cells Indicate Adaptations to Hypoxia*

Janker, Lukas ; Mayer, Rupert L. ; Bileck, Andrea ; Kreutz, Dominique ; Mader, Johanna C. ; Utpatel, Kirsten ; Heudobler, Daniel ; Agis, Hermine ; Gerner, Christopher ; Slany, Astrid



Abstract

Multiple Myeloma (MM) is an incurable plasma cell malignancy primarily localized within the bone marrow (BM). It develops from a premalignant stage, monoclonal gammopathy of undetermined significance (MGUS), often via an intermediate stage, smoldering MM (SMM). The mechanisms of MM progression have not yet been fully understood, all the more because patients with MGUS and SMM already carry ...

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