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Physiological concentrations of denosumab enhance osteogenic differentiation in human mesenchymal stem cells of the jaw bone

Mosch, Alexander ; Ettl, Tobias ; Mamilos, Andreas ; Schreml, Stephan ; Spörl, Steffen ; Spanier, Gerrit ; Klingelhöffer, Christoph


Objective: The aim of this study was to evaluate the possible influence of denosumab and zoledronate on pro-liferation and osteogenic differentiation of alveolar bone stem cells. Design: Mesenchymal stem cells (MSCs) and dental follicle cells (DFCs) were grown under osteogenic differentiation with concentrations from 0.25 mu M to 10 mu M (zoledronate) and to 20 mu M (denosumab). Vitality was ...


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