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PPAR-γ in Macrophages Limits Pulmonary Inflammation and Promotes Host Recovery following Respiratory Viral Infection

Huang, Su ; Zhu, Bibo ; Cheon, In Su ; Goplen, Nick P. ; Jiang, Li ; Zhang, Ruixuan ; Peebles, R. Stokes ; Mack, Matthias ; Kaplan, Mark H. ; Limper, Andrew H. ; Sun, Jie ; García-Sastre, Adolfo



Zusammenfassung

Alveolar macrophages (AM) play pivotal roles in modulating host defense, pulmonary inflammation, and tissue injury following respiratory viral infections. However, the transcriptional regulation of AM function during respiratory viral infections is still largely undefined. Here we have screened the expression of 84 transcription factors in AM in response to influenza A virus (IAV) infection. We ...

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