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Group VIA phospholipase A2 deficiency in mice chronically fed with high-fat-diet attenuates hepatic steatosis by correcting a defect of phospholipid remodeling

Otto, Ann-Christin ; Gan-Schreier, Hongying ; Zhu, Xingya ; Tuma-Kellner, Sabine ; Staffer, Simone ; Ganzha, Alexandra ; Liebisch, Gerhard ; Chamulitrat, Walee



Abstract

A defect of hepatic remodeling of phospholipids (PL) is seen in non-alcoholic fatty liver disease and steatohepatitis (NASH) indicating pivotal role of PL metabolism in this disease. The deletion of group VIA calcium independent phospholipase A2 (iPla2 beta) protects ob/ob mice from hepatic steatosis (BBAIip 1861, 2016, 440-461), however its role in high-fat diet (HFD)-induced NASH is still ...

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