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iPla2β deficiency in mice fed with MCD diet does not correct the defect of phospholipid remodeling but attenuates hepatocellular injury via an inhibition of lipid uptake genes

Zhu, Xingya ; Gan-Schreier, Hongying ; Otto, Ann-Christin ; Cheng, Yuting ; Staffer, Simone ; Tuma-Kellner, Sabine ; Ganzha, Alexandra ; Liebisch, Gerhard ; Chamulitrat, Walee


Group VIA calcium-independent phospholipase A2 (iPla2 beta) is among modifier genes of non-alcoholic fatty liver disease which leads to non-alcoholic steatohepatitis (NASH). Consistently, iPla2 beta deletion protects hepatic steatosis and obesity in genetic ob/ob and obese mice chronically fed with high-fat diet by replenishing the loss of hepatic phospholipids (PL). As mouse feeding with ...


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