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WNT5A supports viability of senescent human dental follicle cells

Morsczeck, Christian ; Reck, Anja ; Reichert, Torsten E.


The osteogenic differentiation of dental follicle cells (DFCs) is inhibited by the onset of cellular senescence, but the cause for this is largely unknown. Recently it was shown that WNT5a, which is an inductor of the non-canonical WNT pathway, stimulates both cellular senescence and osteogenic differentiation of different cell types. In this study, we investigated the role of WNT5a for viability ...


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