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MAdCAM-1-Mediated Intestinal Lymphocyte Homing Is Critical for the Development of Active Experimental Autoimmune Encephalomyelitis

Kuhbandner, Kristina ; Hammer, Anna ; Haase, Stefanie ; Terbrack, Elisa ; Hoffmann, Alana ; Schippers, Angela ; Wagner, Norbert ; Hussain, Rehana Z. ; Miller-Little, William A. ; Koh, Andrew Y. ; Stoolman, Joshua S. ; Segal, Benjamin M. ; Linker, Ralf A. ; Stüve, Olaf


Lymphocyte homing into the intestine is mediated by binding of leukocytes to mucosal addressin cell adhesion molecule 1 (MAdCAM-1), expressed on endothelial cells. Currently, the immune system of the gut is considered a major modulator not only of inflammatory bowel disease, but also of extra-intestinal autoimmune disorders, including multiple sclerosis (MS). Despite of intense research in this ...


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