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HIF1A and NFAT5 coordinate Na+-boosted antibacterial defense via enhanced autophagy and autolysosomal targeting

Neubert, Patrick ; Weichselbaum, Andrea ; Reitinger, Carmen ; Schatz, Valentin ; Schröder, Agnes ; Ferdinand, John R. ; Simon, Michaela ; Bär, Anna-Lorena ; Brochhausen, Christoph ; Gerlach, Roman G. ; Tomiuk, Stefan ; Hammer, Karin ; Wagner, Stefan ; van Zandbergen, Ger ; Binger, Katrina J. ; Müller, Dominik N. ; Kitada, Kento ; Clatworthy, Menna R. ; Kurts, Christian ; Titze, Jens ; Abdullah, Zeinab ; Jantsch, Jonathan


Infection and inflammation are able to induce diet-independent Na+-accumulation without commensurate water retention in afflicted tissues, which favors the pro-inflammatory activation of mouse macrophages and augments their antibacterial and antiparasitic activity. While Na+-boosted host defense against the protozoan parasite Leishmania major is mediated by increased expression of the ...


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