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A humanized bone microenvironment uncovers HIF2 alpha as a latent marker for osteosarcoma

Wagner, Ferdinand ; Holzapfel, Boris M. ; Martine, Laure C. ; McGovern, Jacqui ; Lahr, Christoph A. ; Boxberg, Melanie ; Prodinger, Peter M. ; Grässel, Susanne ; Loessner, Daniela ; Hutmacher, Dietmar W.


The quest for predictive tumor markers for osteosarcoma (OS) has not well progressed over the last two decades due to a lack of preclinical models. The aim of this study was to investigate if microenvironmental modifications in an original humanized in vivo model alter the expression of OS tumor markers. Human bone micro-chips and bone marrow, harvested during hip arthroplasty, were implanted at ...


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