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Side effects by oral application of atmospheric pressure plasma on the mucosa in mice

Eickholz, Peter ; Jablonowski, Lukasz ; Kocher, Thomas ; Schindler, Axel ; Müller, Karolina ; Dombrowski, Frank ; von Woedtke, Thomas ; Arnold, Thomas ; Lehmann, Antje ; Rupf, Stefan ; Evert, Matthias ; Evert, Katja


Cold atmospheric pressure plasma (CAP) has been investigated with promising results for peri-implant diseases treatment. However, prior to in-vivo applications of CAP sources in humans, short-term harmful mucosal damage or other unwanted side effects have to be reviewed. 180 male mice (B6C3F1) were divided into twelve treatment groups (n = 15). The right buccal cheek mucosa was treated with CAP. ...


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