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Functional detection of botulinum neurotoxin serotypes A to F by monoclonal neoepitope-specific antibodies and suspension array technology

von Berg, Laura ; Stern, Daniel ; Pauly, Diana ; Mahrhold, Stefan ; Weisemann, Jasmin ; Jentsch, Lisa ; Hansbauer, Eva-Maria ; Müller, Christian ; Avondet, Marc A. ; Rummel, Andreas ; Dorner, Martin B. ; Dorner, Brigitte G.



Abstract

Botulinum neurotoxins (BoNTs) are the most potent toxins known and cause the life threatening disease botulism. Sensitive and broad detection is extremely challenging due to the toxins' high potency and molecular heterogeneity with several serotypes and more than 40 subtypes. The toxicity of BoNT is mediated by enzymatic cleavage of different synaptic proteins involved in neurotransmitter release ...

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