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The Antisteatotic and Hypolipidemic Effect of Insect Meal in Obese Zucker Rats is Accompanied by Profound Changes in Hepatic Phospholipid and 1-Carbon Metabolism

Meyer, Sandra ; Gessner, Denise K. ; Wen, Gaiping ; Most, Erika ; Liebisch, Gerhard ; Zorn, Holger ; Ringseis, Robert ; Eder, Klaus


Scope The hypothesis is tested that insect meal, which has a low methionine content, reduces the hepatic phosphatidylcholine (PC):phosphatidylethanolamine (PE) ratio, which is a critical determinant of hepatic lipid synthesis, by decreasing availability of the methionine metabolite S-adenosylmethionine (SAM). Methods and results Obese rats (n = 24) are randomly divided into two groups (Obese ...


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