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Percutaneous hepatic perfusion (chemosaturation) with melphalan in patients with intrahepatic cholangiocarcinoma: European multicentre study on safety, short-term effects and survival

Marquardt, Steffen ; Kirstein, Martha M. ; Brüning, Roland ; Zeile, Martin ; Ferrucci, Pier Francesco ; Prevoo, Warner ; Radeleff, Boris ; Trillaud, Hervé ; Tselikas, Lambros ; Vicente, Emilio ; Wiggermann, Philipp ; Manns, Michael P. ; Vogel, Arndt ; Wacker, Frank K.


ObjectivesCholangiocarcinoma is the second most common primary liver tumour with a poor overall prognosis. Percutaneous hepatic perfusion (PHP) is a directed therapy for primary and secondary liver malignancies, and its efficacy and safety have been shown in different entities. The purpose of this study was to prove the safety and efficacy of PHP in patients with unresectable intrahepatic ...


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