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Six versus eight doses of rituximab in patients with aggressive B cell lymphoma receiving six cycles of CHOP: results from the “Positron Emission Tomography-Guided Therapy of Aggressive Non-Hodgkin Lymphomas” (PETAL) trial

Hüttmann, Andreas ; Rekowski, Jan ; Müller, Stefan P. ; Hertenstein, Bernd ; Franzius, Christiane ; Mesters, Rolf ; Weckesser, Matthias ; Kroschinsky, Frank ; Kotzerke, Jörg ; Ganser, Arnold ; Bengel, Frank M. ; La Rosée, Paul ; Freesmeyer, Martin ; Höffkes, Heinz-Gert ; Hertel, Andreas ; Behringer, Dirk ; Prange-Krex, Gabriele ; Griesshammer, Martin ; Holzinger, Jens ; Wilop, Stefan ; Krohn, Thomas ; Raghavachar, Aruna ; Maschmeyer, Georg ; Brink, Ingo ; Schroers, Roland ; Gaska, Tobias ; Bernhard, Helga ; Giagounidis, Aristoteles ; Schütte, Jochen ; Dienst, Ariane ; Hautzel, Hubertus ; Naumann, Ralph ; Klein, Alfred ; Hahn, Dennis ; Pöpperl, Gabriele ; Grube, Matthias ; Marienhagen, Jörg ; Schwarzer, Andreas ; Kurch, Lars ; Höhler, Thomas ; Steiniger, Heike ; Nückel, Holger ; Südhoff, Thomas ; Römer, Wolfgang ; Brinkmann, Marcus ; Ose, Claudia ; Alashkar, Ferras ; Schmitz, Christine ; Dürig, Jan ; Hoelzer, Dieter ; Jöckel, Karl-Heinz ; Klapper, Wolfram ; Dührsen, Ulrich



Abstract

Standard first-line treatment of aggressive B cell lymphoma comprises six or eight cycles of cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) plus eight doses of rituximab (R). Whether adding two doses of rituximab to six cycles of R-CHOP is of therapeutic benefit has not been systematically investigated. The Positron Emission Tomography-Guided Therapy of Aggressive Non-Hodgkin ...

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