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Immune cell derived BDNF does not mediate neuroprotection of the murine anti-CD52 antibody in a chronic autoimmune mouse model

Demir, Seray ; Pitarokoili, Kalliopi ; Linker, Ralf ; Gold, Ralf



Abstract

The murine anti-CD52 antibody, an equivalent of the humanized antibody alemtuzumab, which is successfully used in the treatment of multiple sclerosis, was used to explore a potential neuroprotective effect driven by immune cell derived brain-derived neurotrophic factor (BDNF). Therefore, lineage specific constitutive knockout mice with a BDNF deficiency in T cells and macrophages were used and ...

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