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MEK inhibition suppresses K-Ras wild-type cholangiocarcinoma in vitro and in vivo via inhibiting cell proliferation and modulating tumor microenvironment

Wang, Pan ; Song, Xinhua ; Utpatel, Kirsten ; Shang, Runze ; Yang, Yoon Mee ; Xu, Meng ; Zhang, Jie ; Che, Li ; Gordan, John ; Cigliano, Antonio ; Seki, Ekihiro ; Evert, Matthias ; Calvisi, Diego F. ; Hu, Xiaosong ; Chen, Xin


PD901, a MEK inhibitor, has been demonstrated of therapeutic efficacy against cholangiocarcinoma (CCA) harboring K-Ras oncogenic mutations. However, most CCA exhibit no K-Ras mutations. In the current study, we investigated the therapeutic potential of PD901, either alone or in combination with the pan-mTOR inhibitor MLN0128, for the treatment of K-Ras wild-type CCA in vitro using human CCA cell ...


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