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Piwi-like 1 protein expression is a prognostic factor for renal cell carcinoma patients

Stöhr, Christine G. ; Steffens, Sandra ; Polifka, Iris ; Jung, Rudolf ; Kahlmeyer, Andreas ; Ivanyi, Philipp ; Weber, Florian ; Hartmann, Arndt ; Wullich, Bernd ; Wach, Sven ; Taubert, Helge



Abstract

The Piwi-like genes belong to the Argonaute gene family and are conserved in plants, animals and humans. In addition to their essential role in the germ line and as stem cell-associated genes, Piwi-like proteins play a role in different cancer types but have yet to be studied in renal cell carcinoma (RCC). We investigated tissue micro arrays (TMAs) with tumor samples of two independent cohorts of ...

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