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G-protein-coupled estrogen receptor GPER-1 expression in hormone receptor-positive breast cancer is associated with poor benefit of tamoxifen

Ignatov, Tanja ; Claus, Maria ; Nass, Norbert ; Haybaeck, Johannes ; Seifert, Bernd ; Kalinski, Thomas ; Ortmann, Olaf ; Ignatov, Atanas


BackgroundThe role of G-protein-coupled estrogen receptor 1 (GPER-1) in the development of tamoxifen resistance in breast cancer is a highly controversial issue. The aim of this study was to determine the expression of GPER-1 in the clinical routine under conditions of endocrine treatment.Patients and methodsGPER-1 expression was analyzed in 442 patients with primary invasive breast cancer. ...


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