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Transgenic lysyl oxidase homolog 1 overexpression in the mouse eye results in the formation and release of protein aggregates

Zadravec, Patrick ; Braunger, Barbara M. ; Melzer, Benjamin ; Kroeber, Markus ; Bösl, Michael R. ; Jägle, Herbert ; Schlötzer-Schrehardt, Ursula ; Tamm, Ernst R.



Abstract

Sequence variants in LOXL1 coding for the secreted enzyme lysyl oxidase homolog 1 (LOXL1) associate with pseudoexfoliation (PEX) syndrome, a condition that is characterized by the deposition of extracellular fibrillar PEX material in the anterior eye and other parts of the body. Since the specific role of LOXL1 in the pathogenesis of PEX is unclear, and an increase in its expression was reported ...

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