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Replication-Competent NYVAC-KC Yields Improved Immunogenicity to HIV-1 Antigens in Rhesus Macaques Compared to Nonreplicating NYVAC

Kibler, Karen V. ; Asbach, Benedikt ; Perdiguero, Beatriz ; García-Arriaza, Juan ; Yates, Nicole L. ; Parks, Robert ; Stanfield-Oakley, Sherry ; Ferrari, Guido ; Montefiori, David C. ; Tomaras, Georgia D. ; Roederer, Mario ; Foulds, Kathryn E. ; Forthal, Donald N. ; Seaman, Michael S. ; Self, Steve ; Gottardo, Raphael ; Phogat, Sanjay ; Tartaglia, James ; Barnett, Susan ; Cristillo, Anthony D. ; Weiss, Deborah ; Galmin, Lindsey ; Ding, Song ; Heeney, Jonathan L. ; Esteban, Mariano ; Wagner, Ralf ; Pantaleo, Giuseppe ; Jacobs, Bertram L. ; Silvestri, Guido



Abstract

As part of the continuing effort to develop an effective HIV vaccine, we generated a poxviral vaccine vector (previously described) designed to improve on the results of the RV144 phase III clinical trial. The construct, NYVAC-KC, is a replication-competent, attenuated recombinant of the vaccinia virus strain NYVAC. NYVAC is a vector that has been used in many previous clinical studies but is ...

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