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No Evidence of Microsatellite Instability and Loss of Mismatch-Repair-Protein Expression in Squamous Cell Carcinoma of the Penis

Stoehr, Robert ; Wendler, Olaf ; Giedl, Johannes ; Gaisa, Nadine T. ; Richter, Georg ; Campean, Valentina ; Burger, Maximilian ; Wullich, Bernd ; Bertz, Simone ; Hartmann, Arndt



Abstract

Objective: Microsatellite instability (MSI) and a defective mismatch repair (MMR) system were described as beneficial tumor features for response to immune checkpoint therapy (PD-1 blockade). Meanwhile, the FDA approved PD-1/PD-L1 inhibition treatment for any solid tumor showing MSI and/or defects in the MMR system. For squamous cell carcinoma (SCC) of the penis, no data on the frequency of MSI ...

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