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Functionality and Cell Senescence of CD4/ CD8-Selected CD20 CAR T Cells Manufactured Using the Automated CliniMACS Prodigy® Platform

Aleksandrova, Krasimira ; Leise, Jana ; Priesner, Christoph ; Melk, Anette ; Kubaink, Fanni ; Abken, Hinrich ; Hombach, Andreas ; Aktas, Murat ; Essl, Mike ; Bürger, Iris ; Kaiser, Andrew ; Rauser, Georg ; Jurk, Marion ; Goudeva, Lilia ; Glienke, Wolfgang ; Arseniev, Lubomir ; Esser, Ruth ; Köhl, Ulrike



Abstract

Clinical studies using autologous CAR T cells have achieved spectacular remissions in refractory CD19+ B cell leukaemia, however some of the patient treatments with CAR T cells failed. Beside the heterogeneity of leukaemia, the distribution and senescence of the autologous cells from heavily pretreated patients might be further reasons for this. We performed six consecutive large-scale ...

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