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Bile acid-induced apoptosis and bile acid synthesis are reduced by over-expression of Augmenter of Liver Regeneration (ALR) in a STAT3-dependent mechanism

Ibrahim, Sara ; Dayoub, Rania ; Krautbauer, Sabrina ; Liebisch, Gerhard ; Wege, Anja Kathrin ; Melter, Michael ; Weiss, Thomas S.



Abstract

Cholestasis represents pathophysiologic syndromes defined as an impaired bile flow from the liver. As an outcome, bile acids accumulate and promote hepatocytes injury followed by liver cirrhosis and liver failure. Bile acids induce apoptosis, ER stress and mitochondrial membrane instability. In this study we aimed to investigate the role of cytosolic short form of ALR (Augmenter of Liver ...

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