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Elevation of blood lipids in hepatocyte-specific fatty acid transport 4-deficient mice fed with high glucose diets

Döring, Stephan ; Seeßle, Jessica ; Gan-Schreier, Hongying ; Javaheri, Bahador ; Jiao, Li ; Cheng, Yuting ; Tuma-Kellner, Sabine ; Liebisch, Gerhard ; Herrmann, Thomas ; Stremmel, Wolfgang ; Chamulitrat, Walee


Fatty acid transport protein4 (FATP4) is upregulated in acquired and central obesity and its polymorphisms are associated with blood lipids and insulin resistance. Patients with FATP4 mutations and mice with global FATP4 deletion exhibit skin abnormalities characterized as ischthyosis prematurity syndrome (IPS). Cumulating data have shown that an absence of FATP4 increases the levels of cellular ...


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