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Expression of proton‐sensing G‐protein‐coupled receptors in selected skin tumors

Nassios, Anaïs ; Wallner, Susanne ; Haferkamp, Sebastian ; Klingelhöffer, Christoph ; Brochhausen, Christoph ; Schreml, Stephan



Abstract

Background In humans, there are four known proton-sensing G-Protein-coupled receptors (pH-GPCRs): GPR4 (GPR19), TDAG8 (GPR65, T-cell death-associated gene 8), OGR1 (GPR68, ovarian cancer GPCR1) and G2A (GPR132, G2 accumulation protein). They are known to be involved in sensing changes of extracellular proton concentrations in the acidic microenvironment of tumors, which leads to altered cell ...

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