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Stimulation of TNF receptor type 2 expands regulatory T cells and ameliorates established collagen-induced arthritis in mice

Lamontain, Vanessa ; Schmid, Tobias ; Weber-Steffens, Dorothea ; Zeller, David ; Jenei-Lanzl, Zsuzsa ; Wajant, Harald ; Straub, Rainer H. ; Männel, Daniela N.



Abstract

Tumor necrosis factor (TNF) and its receptors TNF receptor type 1 (TNFR1) and type 2 (TNFR2) have a central role in chronic inflammatory diseases. While TNFR1 mainly confers inflammation, activation of TNFR2 elicits not only pro-inflammatory but also anti-inflammatory effects. In this study, we wanted to investigate the anti-inflammatory therapeutic potential of selective activation of TNFR2 in ...

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