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Combined CDK4/6 and Pan-mTOR Inhibition Is Synergistic Against Intrahepatic Cholangiocarcinoma

Song, Xinhua ; Liu, Xianqiong ; Wang, Haichuan ; Wang, Jingxiao ; Qiao, Yu ; Cigliano, Antonio ; Utpatel, Kirsten ; Ribback, Silvia ; Pilo, Maria G. ; Serra, Marina ; Gordan, John D. ; Che, Li ; Zhang, Shanshan ; Cossu, Antonio ; Porcu, Alberto ; Pascale, Rosa M. ; Dombrowski, Frank ; Hu, Hongbo ; Calvisi, Diego F. ; Evert, Matthias ; Chen, Xin



Abstract

Purpose: Intrahepatic cholangiocarcinoma (ICC) is an aggressive cancer type, lacking effective therapies and associated with a dismal prognosis. Palbociclib is a selective CDK4/6 inhibitor, which has been shown to suppress cell proliferation in many experimental cancer models. Recently, we demonstrated that pan-mTOR inhibitors, such as MLN0128, effectively induce apoptosis, although have limited ...

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