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Profiling of aberrant DNA methylation in acute myeloid leukemia reveals subclasses of CG-rich regions with epigenetic or genetic association

Gebhard, Claudia ; Glatz, Dagmar ; Schwarzfischer, Lucia ; Wimmer, Julia ; Stasik, Sebastian ; Nuetzel, Margit ; Heudobler, Daniel ; Andreesen, Reinhard ; Ehninger, Gerhard ; Thiede, Christian ; Rehli, Michael


Malignant transformation is frequently associated with disease-specific epigenetic alterations, but the underlying mechanisms and pathophysiological consequences remain poorly understood. Here, we used global comparative DNA methylation profiling at CG-rich regions of 27 acute myeloid leukemia (AML) samples to select a subset of aberrantly methylated CG-rich regions (similar to 400 regions, ...


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