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Y chromosome mosaicism is associated with age-related macular degeneration

Grassmann, Felix ; Kiel, Christina ; den Hollander, Anneke I. ; Weeks, Daniel E. ; Lotery, Andrew ; Cipriani, Valentina ; Weber, Bernhard H. F.



Zusammenfassung

Age-related macular degeneration (AMD) is the leading cause of blindness in industrialised countries, and thereby a major individual but also a socio-economic burden. Y chromosome loss in nucleated blood cells has been implicated in age-related diseases such as Alzheimer disease and was shown to be caused by increasing age, smoking and genetic factors. Mosaic loss of Y chromosome (mLOY) in ...

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