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SGLT2 Inhibitors and Their Mode of Action in Heart Failure—Has the Mystery Been Unravelled?

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Pabel, Steffen ; Hamdani, Nazha ; Luedde, Mark ; Sossalla, Samuel
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 12 Oct 2021 05:18


Purpose of review SGLT2 inhibitors (SGLT2i) are new drugs for patients with heart failure (HF) irrespective of diabetes. However, the mechanisms of SGLT2i in HF remain elusive. This article discusses the current clinical evidence for using SGLT2i in different types of heart failure and provides an overview about the possible underlying mechanisms. Recent findings Clinical and basic data ...


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