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Biomarker-guided preemption of steroid-refractory graft-versus-host disease with α-1-antitrypsin

Gergoudis, Stephanie C. ; DeFilipp, Zachariah ; Özbek, Umut ; Sandhu, Karamjeet S. ; Etra, Aaron M. ; Choe, Hannah K. ; Kitko, Carrie L. ; Ayuk, Francis ; Aziz, Mina ; Baez, Janna ; Ben-David, Kaitlyn ; Bunworasate, Udomsak ; Gandhi, Isha ; Hexner, Elizabeth O. ; Hogan, William J. ; Holler, Ernst ; Kasikis, Stelios ; Kowalyk, Steven M. ; Lin, Jung-Yi ; Merli, Pietro ; Morales, George ; Nakamura, Ryotaro ; Reshef, Ran ; Rösler, Wolf ; Srinagesh, Hrishikesh ; Young, Rachel ; Chen, Yi-Bin ; Ferrara, James L. M. ; Levine, John E.



Abstract

Steroid-refractory (SR) acute graft-versus-host disease (GVHD) remains a major cause of nonrelapse mortality (NRM) after allogeneic hematopoietic cell transplantation (HCT), but its occurrence is not accurately predicted by pre-HCT clinical risk factors. The Mount Sinai Acute GVHD International Consortium (MAGIC) algorithm probability (MAP) identifies patients who are at high risk for developing ...

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