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A novel mouse model of obstructive sleep apnea by bulking agent-induced tongue enlargement results in left ventricular contractile dysfunction

Bader, Michael ; Lebek, Simon ; Hegner, Philipp ; Schach, Christian ; Reuthner, Kathrin ; Tafelmeier, Maria ; Maier, Lars Siegfried ; Arzt, Michael ; Wagner, Stefan


Aims Obstructive sleep apnea (OSA) is a widespread disease with high global socio-economic impact. However, detailed pathomechanisms are still unclear, partly because current animal models of OSA do not simulate spontaneous airway obstruction. We tested whether polytetrafluoroethylene (PTFE) injection into the tongue induces spontaneous obstructive apneas. Methods and results PTFE (100 mu l) was ...


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