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Mitochondrial DNA mutations induce mitochondrial biogenesis and increase the tumorigenic potential of Hodgkin and Reed–Sternberg cells

Haumann, Sophie ; Boix, Julia ; Knuever, Jana ; Bieling, Angela ; Vila Sanjurjo, Anton ; Elson, Joanna L. ; Blakely, Emma L. ; Taylor, Robert W. ; Riet, Nicole ; Abken, Hinrich ; Kashkar, Hamid ; Hornig-Do, Hue-Tran ; Wiesner, Rudolf J.



Abstract

Functioning mitochondria are crucial for cancer metabolism, but aerobic glycolysis is still considered to be an important pathway for energy production in many tumor cells. Here we show that two well established, classic Hodgkin lymphoma (cHL) cell lines harbor deleterious variants within mitochondrial DNA (mtDNA) and thus exhibit reduced steady-state levels of respiratory chain complexes. ...

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