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Regulation of Autophagic Signaling by Mechanical Loading and Inflammation in Human PDL Fibroblasts

Blawat, Kim ; Mayr, Alexandra ; Hardt, Miriam ; Kirschneck, Christian ; Nokhbehsaim, Marjan ; Behl, Christian ; Deschner, James ; Jäger, Andreas ; Memmert, Svenja



Abstract

Autophagy (cellular self-consumption) is a crucial adaptation mechanism during cellular stress conditions. This study aimed to examine how this important process is regulated in human periodontal ligament (PDL) fibroblasts by mechanical and inflammatory stress conditions and whether the mammalian target of rapamycin (mTOR) signaling pathway is involved. Autophagy was quantified by flow cytometry. ...

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