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Circulating Interleukin-4 Is Associated with a Systemic T Cell Response against Tumor-Associated Antigens in Treatment-Naïve Patients with Resectable Non-Small-Cell Lung Cancer

Safi, Seyer ; Yamauchi, Yoshikane ; Hoffmann, Hans ; Weichert, Wilko ; Jost, Philipp J. ; Winter, Hauke ; Muley, Thomas ; Beckhove, Philipp


Simple Summary Cytokines can increase the activity of T cells specific for tumor-associated antigens and thereby promote tumor-specific immune responses. In this study, cytokine profiles and T cell responses against 14 tumor-associated antigens were investigated in 36 treatment-naive patients with resectable non-small cell lung cancer. Based on these results, preoperative serum interleukin-4 ...


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