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Lymphatic and vascular invasion in oral squamous cell carcinoma: Implications for recurrence and survival in a population-based cohort study

Spoerl, Steffen ; Gerken, Michael ; Fischer, René ; Mamilos, Andreas ; Spoerl, Silvia ; Wolf, Stefanie ; Pohl, Fabian ; Klingelhöffer, Christoph ; Ettl, Tobias ; Reichert, Torsten E. ; Spanier, Gerrit


Objective: Numerous studies analyzed lymphovascular invasion (LVI) in various malignant diseases, however, little is known about the role of lymphatic invasion (LI) as well as vascular invasion (VI) in oral squamous cell carcinoma (OSCC). The aim of this study is to illuminate the role of LI and VI in a population-based cohort study. Methods: We retrospectively analyzed 745 primarily resected ...


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