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Absence of nuclear receptors LXRs impairs immune response to androgen deprivation and leads to prostate neoplasia

Meier, Pascal ; Bousset, Laura ; Septier, Amandine ; Bunay, Julio ; Voisin, Allison ; Guiton, Rachel ; Damon-Soubeyrant, Christelle ; Renaud, Yoan ; De Haze, Angélique ; Sapin, Vincent ; Fogli, Anne ; Rambur, Amandine ; De Joussineau, Cyrille ; Kocer, Ayhan ; Trousson, Amalia ; Henry-Berger, Joëlle ; Höring, Marcus ; Liebisch, Gerhard ; Matysik, Silke ; Lobaccaro, Jean-Marc A. ; Morel, Laurent ; Baron, Silvère


Chronic inflammation is now a well-known precursor for cancer development. Infectious prostatitis are the most common causes of prostate inflammation, but emerging evidence points the role of metabolic disorders as a potential source of cancer-related inflammation. Although the widely used treatment for prostate cancer based on androgen deprivation therapy (ADT) effectively decreases tumor size, ...


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